Johnson City serves as a regional medical center for northeast Tennessee and southwest Virginia, along with parts of western North Carolina and Kentucky. Although there are two major hospital systems in the Tri-Cities, only one – Mountain States Health Alliance – has a presence in Johnson City.
The Johnson City Medical Center, designated a Level 1 Trauma Center by the State of Tennessee, is MSHA's flagship institution. Also affiliated with the center are the Niswonger Children's Hospital, a domestic affiliate of St. Jude Children's Research Hospital and Woodridge Hospital, a mental health and chemical dependency facility.
Franklin Woods Community Hospital is a LEED-certified facility located in North Johnson City. The "green" hospital (opened July 12, 2010) encloses approximately 240,000 square feet (22,000 m2) on a 25-acre (100,000 m2) lot adjacent to The Wellness Center inside MedTech Park. The hospital has 80 licensed beds and a 22-room Emergency Department. Of the licensed beds, 20 are dedicated to Women’s and Children’s Services.
The James H. & Cecile C. Quillen Rehabilitation Hospital, also located in North Johnson City, serves patients who have suffered debilitating trauma, including stroke and brain-spine injuries.
Additionally, the James H. Quillen VA Medical Center, located in the Mountain Home community in Johnson City's southside, serves veterans in the four-state region. The center is closely involved with the ETSU College of Medicine. | 
